2′,4′-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis
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منابع مشابه
In vitro Apoptosis Induction in Prostate Cancer Cells (PC-3) using Bacillus licheniformis Supernatant
Background: Cancer is one of the most common causes of death in humans. Therefore, there is a need for new cytotoxic compounds from natural sources such as native bacteria. The current study aimed at investigating the cytotoxic effects of compounds obtained from gram-positive terricolous bacteria on the apoptosis of cells in prostate cancer (PC-3). Materials & Methods: A total of 70 s...
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Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...
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Dendrostellera lessertii (Thymelaeaceae) is a toxic plant that grows in parts of Iran. The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines. Methods: In a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...
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tgiflx, a homoproteins cluster member located on the x chromosome, has a critical role in male reproduction and prostate development. previous studies have shown the erratic expression of tgiflx gene in a large proportion of prostate tumors. however tgiflx function in prostate development remains unknown. the purpose of this study was to evaluate the consequences of tgiflx expression on prostat...
متن کاملFenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells.
N-(4-Hydroxyphenyl)retinamide (4-HPR, Fenretinide) is a retinoid derivative with antineoplastic activity in various tumor types including prostate carcinoma. The mechanism of action of 4-HPR toxicity is unknown. 4-HPR induces apoptosis in leukemia- and lymphoma-derived cells, neuroblastoma, and small cell lung cancers. The present study was designed to investigate: (a) the mechanism of 4-HPR cy...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2015
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2015.3795